Lola Karimova-Tillyaeva heads two charitable organizations in Uzbekistan, which help orphaned children and children with disabilities. The “You are not Alone” Foundation was established by Karimova-Tillyaeva in 2002 to provide assistance to orphanages and children left without parental care in Uzbekistan.
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Two years later, Karimova-Tillyaeva founded the National Centre for the Social Adaptation of Children, a charitable organization which provides medical and educational assistance to children with disabilities.